司美格鲁肽(Saxenda) vs 曼扎罗(Mounjaro), in fact, 曼扎罗(Mounjaro) has a clear victory.

Hello, I am Dr. Wi Young-jin from Beauty Stone, Seoul National University.

"I am using 司美格鲁肽(Saxenda), but I’ve heard 曼扎罗(Mounjaro) is better. Should I switch?"

Since both have been mentioned a lot on TV and social media, there are quite a few people who actually don't know the exact differences between the two.

1. 司美格鲁肽(Saxenda) vs 曼扎罗(Mounjaro), in fact, 曼扎罗(Mounjaro) has a clear victory.

Many people think, 'Aren't both just injections for weight loss?'

The principle of action itself is a clear win for 曼扎罗(Mounjaro).

司美格鲁肽(Saxenda) - GLP-1 > prevents hunger

曼扎罗(Mounjaro) - GLP-1 + GIP appetite suppression and blood sugar control

What difference does it make that it works on GIP too? This is actually a quite significant difference.

It also improves insulin sensitivity.

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** FAQ**

**Q. Isn't 曼扎罗(Mounjaro) a diabetes medication?**

Originally, it is approved as a treatment for type 2 diabetes. However, its weight loss effect has been confirmed in clinical settings, so it is also used for obesity treatment. 司美格鲁肽(Saxenda) started from diabetes treatment as well.

**Q. 司美格鲁肽(Saxenda) is an old medication, does it lose efficacy?**

Just because it’s old doesn’t mean it’s ineffective. 司美格鲁肽(Saxenda) is a proven medication backed by sufficient clinical data. However, since 曼扎罗(Mounjaro) is relatively new, you could say it has added mechanisms of action.

**Q. Do I have to take both every day?**

司美格鲁肽(Saxenda) is a self-injection once a day, while 曼扎罗(Mounjaro) is once a week. The difference in administration frequency is also something to consider when choosing.

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2. So, how much difference is there in actual weight loss effects?

This is what you are most curious about.

When comparing based on clinical research standards, 曼扎罗(Mounjaro) tends to show a greater weight loss than 司美格鲁肽(Saxenda).

For 司美格鲁肽(Saxenda), an average weight loss of about 5-8% was reported in large-scale clinical studies,

while studies have reported weight loss effects of up to 15-20% for 曼扎罗(Mounjaro).

Of course, this **depends completely on individual eating habits, underlying conditions, and lifestyle.**

曼扎罗(Mounjaro) has a clear win, but if you have hypersensitivity or significant gastrointestinal discomfort,

you cannot use it.

Regarding side effects, both medications may initially cause symptoms such as nausea, vomiting, and indigestion.

These reactions can mostly be minimized by gradually increasing the dosage.

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** FAQ**

**Q. If 曼扎罗(Mounjaro) is more effective, does that mean the side effects are worse?**

Since it works doubly, some people may feel initial gastrointestinal side effects similarly or even slightly more intensely. Therefore, it’s recommended to start with a low dosage and gradually increase it.

**Q. 曼扎罗(Mounjaro) is expensive, does that guarantee effectiveness?**

There are no medications that can guarantee effectiveness. However, it is true that it has a clinically stronger mechanism of action. Rather than weighing the cost against effectiveness, it is more important to choose a medication that suits your body condition.

**Q. Will I regain weight after losing it?**

Both medications tend to have a return of appetite and weight regain once discontinued. Therefore, it’s important to improve eating habits alongside medication.

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3. Being expensive doesn’t mean it's better – there’s a choice that suits you

Just because 曼扎罗(Mounjaro) is a stronger medication does not mean it is necessarily the correct choice.

Check the criteria below.

| | **司美格鲁肽(Saxenda)** | **曼扎罗(Mounjaro)** |

|---|---|---|

| Mechanism of Action | GLP-1 alone | GLP-1 + GIP dual |

| Administration Method | Self-injection daily | Self-injection once a week |

| Weight Loss Amount | Relatively gradual | Relatively greater |

| Cost | Relatively low | Relatively high |

| Suitable For | Those starting for the first time, budget-conscious individuals | Those who found 司美格鲁肽(Saxenda) ineffective, those wanting quicker weight loss |

司美格鲁肽(Saxenda)

曼扎罗(Mounjaro)

Mechanism of Action

GLP-1 alone

GLP-1 + GIP

Administration Method

Self-injection daily

Self-injection once a week

Weight Loss Amount

Relatively gradual

Relatively greater

Cost

Relatively low

Relatively high

Especially for those with thyroid-related diseases or a history of pancreatitis, it is essential to get a prescription after a consultation.

Purchasing online or adjusting the dosage on your own is strongly discouraged.

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** FAQ**

**Q. I didn't feel much effect from 司美格鲁肽(Saxenda). Will switching to 曼扎罗(Mounjaro) make a difference?**

There are cases where those who did not respond to 司美格鲁肽(Saxenda) experience effects after switching to 曼扎罗(Mounjaro). However, this varies by individual and the accompanying lifestyle habits also have a significant impact. It’s advisable to decide after consultation.

**Q. Can I get these medications prescribed by a dermatologist?**

Yes, that’s correct. Obesity-related diet injections can also be prescribed by dermatologists. A benefit of consulting dermatology is that it allows for consideration of body shape management and skin elasticity care together.

**Q. How often should I take it? Is there a set period?**

There is no fixed period, and it depends on whether weight maintenance is achieved after reaching the target weight. Usually, it is often monitored over a period of three months or more.

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## Conclusion

The question of whether 曼扎罗(Mounjaro) or 司美格鲁肽(Saxenda) is better is less important than the question of "which one suits my body?"

Even the same medication may work well for one person and not for another.

You must discuss your current weight, health status, and lifestyle in a consultation to make the right choice.

Come to Beauty Stone Dermatology in Hongdae for a free consultation.

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`曼扎罗(Mounjaro) vs 司美格鲁肽(Saxenda)`, `Diet Injection Comparison`, `曼扎罗(Mounjaro) Effects`, `Difference Between 司美格鲁肽(Saxenda) and 曼扎罗(Mounjaro)`, `Hongdae Dermatology Diet`, `Obesity Injection Recommendation`, `曼扎罗(Mounjaro) Side Effects`

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