
Radiesse effect—does it really stimulate collagen production?
Radiesse effect—does it really stimulate collagen production?
Radiesse effect—does it really stimulate collagen production?
For those wondering whether the Radiesse effect is real, I’ve put together a detailed explanation of how calcium hydroxyapatite stimulates collagen production and the clinical experience behind it.

Radiesse effect,
does it really create collagen?
I'm Clinic Director Wi Young-jin from Beautys Doctor.
Check this before reading
Q. Isn't Radiesse just a filler that adds volume?
A. It does add volume, but
the key is calcium hydroxyapatite (CaHA)
particles inducing collagen production
in the 'dual effect.'
Q. Isn't the claim that it makes collagen
just marketing?
A. It is a mechanism backed by evidence,
with actual new collagen confirmed in histological studies.
Key points of this article
It is true that Radiesse creates collagen
—How calcium hydroxyapatite works

What is Radiesse?
Radiesse is
a collagen-stimulating filler with micro-particles of calcium hydroxyapatite (CaHA)
dispersed in a CMC gel carrier.
It is a collagen-stimulating filler.
Unlike ordinary HA (hyaluronic acid) fillers
that focus on 'adding volume,'
Radiesse is designed with the goal of
'filling while simultaneously
changing the skin itself.'

The real principle behind
how calcium hydroxyapatite creates collagen
This is the part many people misunderstand,
because when you say 'it makes collagen,'
it sounds a bit exaggerated, right?
The main ingredient in Radiesse,
calcium hydroxyapatite (CaHA),
is also found in our bones and teeth.
In other words, it is biocompatible.
When these CaHA microparticles enter the dermis
they begin stimulating fibroblasts
in the surrounding tissue.
Fibroblasts are cells like a 'factory' that makes collagen,
and the CaHA particles
send that factory a 'work order.'
To be honest, this process is a bit slow.
Right after injection, the gel carrier provides volume,
and meanwhile around the CaHA particles
new collagen gradually forms.
Over time, the gel is absorbed and
the CaHA particles are also broken down,
but the newly formed collagen remains in place.
That is the essence of the Radiesse effect.
The reason the effect lasts even after the filler is gone
is precisely this collagen retention effect.
CaHA particles are tiny bead-like particles with a diameter of 25~45μm
in size.
These particles, within the dermis,
act as a kind of 'scaffold'
that encourages collagen to build up on top of them.
When constructing a building, you first set up the rebar
and then pour concrete on top,
CaHA plays the role of the rebar,
and collagen becomes the concrete.
It is not simply filling empty space,
but a method that draws out the tissue's own regenerative power.
Director Wi Young-jin's key summary
Right after injection, the gel holds the volume,
and over weeks to months
the CaHA particles induce collagen production.
Even after the filler ingredients are broken down,
new collagen remains,
so the duration of effect is relatively long.
'Filling + regeneration'
is the structure at work simultaneously.

Radiesse vs HA filler vs Sculptra comparison
Category | HA filler | Radiesse (CaHA) | Sculptra (PLLA) |
Main ingredient | Hyaluronic acid | Calcium hydroxyapatite | Poly-L-lactic acid |
Immediate volume | Possible | Possible | Not possible (gradual) |
Collagen stimulation | Minimal | Moderate | Strong |
Duration | 6~12 months | 12~18 months | 18~24 months |
Can be dissolved | Yes (hyaluronidase) | No | No |
Suitable areas | Lips, tear troughs, etc. | Jawline, nose, cheeks, backs of the hands | Volume lifting over large areas |
There is one important thing I have to mention about Radiesse:
it cannot be dissolved like HA filler.
If the result with hyaluronic acid filler is not to your liking,
it can be dissolved with hyaluronidase,
but that is not possible with Radiesse.
That is why the injector's anatomical understanding
and control of the injection amount are much more important.
If too much is injected without enough experience,
it is difficult to correct.
That said, because of this,
if you leave it to experienced medical staff,
you can expect more precise and longer-lasting results.

Who does the Radiesse effect work best for?
1. People who want volume and elasticity at the same time
If you feel like you've lost cheek volume and the skin has started to sag as well,
Radiesse can be effective.
2. People who want fewer procedures
Among those who used to repeat HA filler every 6 months,
many say they switched to Radiesse and
their maintenance period got longer.
3. Areas with thin skin such as the backs of the hands and forearms
Recently, Radiesse has also been diluted
and injected thinly over a wide area
using a 'hyperdilution' technique
to improve skin texture.
Frequently asked questions
Q1. Do you bruise a lot after Radiesse?
It depends on the injection site, but
it is similar to ordinary fillers.
Using a cannula
can significantly reduce bruising.
Q2. How much does it cost, and how many sessions are needed?
The unit price is higher than HA filler, but because the duration is longer,
if you look at the total cost over a one-year period,
the difference may not be large.
Usually, most people are satisfied with 1~2 sessions.
Q3. I heard nodules (lumps) can form?
They can occur if too much is injected or if it is placed too superficially.
It should not be used in areas where the skin is very thin,
such as the lips or tear troughs.
That is the rule.
KakaoTalk consultation before your visit is also available.
This has been Wi Young-jin.
Read together
▶If Sculptra makes the back cheek look bulging, the method is wrong
▶Shoulder filler effects and side effects, 3 key principles for creating square shoulders
▶Chin filler side effects, effects, and duration — I'll summarize everything at once
▶One shot and done? Radiesse dilution methods and effects
▶Why does the bridge of the nose get thicker after nose filler?

Radiesse effect,
does it really create collagen?
I'm Clinic Director Wi Young-jin from Beautys Doctor.
Check this before reading
Q. Isn't Radiesse just a filler that adds volume?
A. It does add volume, but
the key is calcium hydroxyapatite (CaHA)
particles inducing collagen production
in the 'dual effect.'
Q. Isn't the claim that it makes collagen
just marketing?
A. It is a mechanism backed by evidence,
with actual new collagen confirmed in histological studies.
Key points of this article
It is true that Radiesse creates collagen
—How calcium hydroxyapatite works

What is Radiesse?
Radiesse is
a collagen-stimulating filler with micro-particles of calcium hydroxyapatite (CaHA)
dispersed in a CMC gel carrier.
It is a collagen-stimulating filler.
Unlike ordinary HA (hyaluronic acid) fillers
that focus on 'adding volume,'
Radiesse is designed with the goal of
'filling while simultaneously
changing the skin itself.'

The real principle behind
how calcium hydroxyapatite creates collagen
This is the part many people misunderstand,
because when you say 'it makes collagen,'
it sounds a bit exaggerated, right?
The main ingredient in Radiesse,
calcium hydroxyapatite (CaHA),
is also found in our bones and teeth.
In other words, it is biocompatible.
When these CaHA microparticles enter the dermis
they begin stimulating fibroblasts
in the surrounding tissue.
Fibroblasts are cells like a 'factory' that makes collagen,
and the CaHA particles
send that factory a 'work order.'
To be honest, this process is a bit slow.
Right after injection, the gel carrier provides volume,
and meanwhile around the CaHA particles
new collagen gradually forms.
Over time, the gel is absorbed and
the CaHA particles are also broken down,
but the newly formed collagen remains in place.
That is the essence of the Radiesse effect.
The reason the effect lasts even after the filler is gone
is precisely this collagen retention effect.
CaHA particles are tiny bead-like particles with a diameter of 25~45μm
in size.
These particles, within the dermis,
act as a kind of 'scaffold'
that encourages collagen to build up on top of them.
When constructing a building, you first set up the rebar
and then pour concrete on top,
CaHA plays the role of the rebar,
and collagen becomes the concrete.
It is not simply filling empty space,
but a method that draws out the tissue's own regenerative power.
Director Wi Young-jin's key summary
Right after injection, the gel holds the volume,
and over weeks to months
the CaHA particles induce collagen production.
Even after the filler ingredients are broken down,
new collagen remains,
so the duration of effect is relatively long.
'Filling + regeneration'
is the structure at work simultaneously.

Radiesse vs HA filler vs Sculptra comparison
Category | HA filler | Radiesse (CaHA) | Sculptra (PLLA) |
Main ingredient | Hyaluronic acid | Calcium hydroxyapatite | Poly-L-lactic acid |
Immediate volume | Possible | Possible | Not possible (gradual) |
Collagen stimulation | Minimal | Moderate | Strong |
Duration | 6~12 months | 12~18 months | 18~24 months |
Can be dissolved | Yes (hyaluronidase) | No | No |
Suitable areas | Lips, tear troughs, etc. | Jawline, nose, cheeks, backs of the hands | Volume lifting over large areas |
There is one important thing I have to mention about Radiesse:
it cannot be dissolved like HA filler.
If the result with hyaluronic acid filler is not to your liking,
it can be dissolved with hyaluronidase,
but that is not possible with Radiesse.
That is why the injector's anatomical understanding
and control of the injection amount are much more important.
If too much is injected without enough experience,
it is difficult to correct.
That said, because of this,
if you leave it to experienced medical staff,
you can expect more precise and longer-lasting results.

Who does the Radiesse effect work best for?
1. People who want volume and elasticity at the same time
If you feel like you've lost cheek volume and the skin has started to sag as well,
Radiesse can be effective.
2. People who want fewer procedures
Among those who used to repeat HA filler every 6 months,
many say they switched to Radiesse and
their maintenance period got longer.
3. Areas with thin skin such as the backs of the hands and forearms
Recently, Radiesse has also been diluted
and injected thinly over a wide area
using a 'hyperdilution' technique
to improve skin texture.
Frequently asked questions
Q1. Do you bruise a lot after Radiesse?
It depends on the injection site, but
it is similar to ordinary fillers.
Using a cannula
can significantly reduce bruising.
Q2. How much does it cost, and how many sessions are needed?
The unit price is higher than HA filler, but because the duration is longer,
if you look at the total cost over a one-year period,
the difference may not be large.
Usually, most people are satisfied with 1~2 sessions.
Q3. I heard nodules (lumps) can form?
They can occur if too much is injected or if it is placed too superficially.
It should not be used in areas where the skin is very thin,
such as the lips or tear troughs.
That is the rule.
KakaoTalk consultation before your visit is also available.
This has been Wi Young-jin.
Read together
▶If Sculptra makes the back cheek look bulging, the method is wrong
▶Shoulder filler effects and side effects, 3 key principles for creating square shoulders
▶Chin filler side effects, effects, and duration — I'll summarize everything at once
▶One shot and done? Radiesse dilution methods and effects
▶Why does the bridge of the nose get thicker after nose filler?
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