
CelluDM Effect: Why It Fades After 4–6 Months — The Collagen Principle
CelluDM Effect: Why It Fades After 4–6 Months — The Collagen Principle
CelluDM Effect: Why It Fades After 4–6 Months — The Collagen Principle
The Cell-DM effect: the added volume is visible right away the next day, but why does it fade within six months? In our clinic, we explain the concept of “borrowed collagen,” which 70 out of 100 patients come in not knowing.

Selrdiem effect,
why it fades in 4–6 months
— the collagen principle
Last Friday, a patient came into the consultation room
saying they wanted to try Selrdiem once,
and they had printed out a stack of materials.
"Doctor, if I get this once, it lasts a year, right?
I heard it’s a collagen procedure."
This question is the starting point for today’s post.
Let me walk you through, step by step, why Selrdiem’s effect
lasts only that long, starting with the principle.

Selrdiem, compared with other collagen procedures,
here’s what makes it different
Selrdiem is a 'collagen filling' procedure that directly injects
animal-derived atelocollagen into the skin.
It is different in nature from procedures like Juvelook or Rejuran
that stimulate your skin to produce its own collagen.
If stimulation-type treatments wake up the skin
over time,
Selrdiem brings in collagen itself and
fills it in.
That’s why the volume is visible
from the next day.

Why does it show quickly but fade quickly,
really?
"Selrdiem is a treatment that directly replenishes collagen,
so you can see volume the very next day,
but it usually lasts 4–6 months.
Since it doesn’t build your own collagen,
but rather 'borrows' collagen itself,
it needs regular replenishment to maintain the result."
— Dr. Wi Young-jin (Beautystone Clinic, Hongdae)
Anything borrowed is eventually broken down
and fades over time.
Clinically, the usual duration is about 4–6 months,
with around 5 months being average depending on
skin thickness and metabolic rate.
In the first week, you see a filled-in look along with
mild swelling, and
it settles in over weeks 2–4,
when satisfaction is highest.
But it starts to gradually diminish after 3 months,
and by 6 months it returns to about 70–80% of the
pre-treatment level.
For people who exercise a lot or have a fast metabolism,
it may fade sooner, around 4 months.
Who Selrdiem suits well
vs. who may be better served by other treatments
Take a look and compare based on your situation.
Type | Recommended approach | Reason |
People with an important event 3–4 weeks away | Selrdiem | Immediate volume, quick settling |
People wanting long-term skin improvement | Juvelook · Rejuran | Stimulation-type treatment that boosts your own collagen production |
People who want to reduce maintenance cost | Stimulation-type treatments | Selrdiem needs replenishment every 4–6 months |
First-time collagen treatment | Combination treatment | Immediate effect + long-term contour building |
It is a good choice for those who need results in a short time,
but
over the course of a year, costs can add up.
So I recommend getting the quick effect while also
setting up a long-term stimulation-type treatment.
3 questions people really ask
before getting Selrdiem
Q1. Can you see results with just one session?
Yes, the volume itself is visible immediately after injection.
However, you should expect it to return to baseline after 4–6 months.
Think of it not as a 'one-and-done' treatment,
but as something that lasts about half a year.
Q2. How many times a year should I get it?
On average, 2–3 times a year at 4–5 month intervals.
At first, I recommend a touch-up at the 2-month mark to define the line,
then moving to 6-month intervals after that.
Q3. Does it become uneven as it fades?
Because it breaks down naturally,
it rarely fades in an irregular way.
However, for a few days after treatment,
tiny granules may be felt,
and if the depth is set incorrectly, they can become visible on the surface,
so expertise matters.
If you take away just one thing today —
Selrdiem is not a treatment that 'builds' but one that 'fills,'
and what is filled will eventually fade.
In the next post,
I’ll explain the interval when using Selrdiem together with
stimulation-type treatments.
This was Dr. Wi Young-jin.
Read more

Selrdiem effect,
why it fades in 4–6 months
— the collagen principle
Last Friday, a patient came into the consultation room
saying they wanted to try Selrdiem once,
and they had printed out a stack of materials.
"Doctor, if I get this once, it lasts a year, right?
I heard it’s a collagen procedure."
This question is the starting point for today’s post.
Let me walk you through, step by step, why Selrdiem’s effect
lasts only that long, starting with the principle.

Selrdiem, compared with other collagen procedures,
here’s what makes it different
Selrdiem is a 'collagen filling' procedure that directly injects
animal-derived atelocollagen into the skin.
It is different in nature from procedures like Juvelook or Rejuran
that stimulate your skin to produce its own collagen.
If stimulation-type treatments wake up the skin
over time,
Selrdiem brings in collagen itself and
fills it in.
That’s why the volume is visible
from the next day.

Why does it show quickly but fade quickly,
really?
"Selrdiem is a treatment that directly replenishes collagen,
so you can see volume the very next day,
but it usually lasts 4–6 months.
Since it doesn’t build your own collagen,
but rather 'borrows' collagen itself,
it needs regular replenishment to maintain the result."
— Dr. Wi Young-jin (Beautystone Clinic, Hongdae)
Anything borrowed is eventually broken down
and fades over time.
Clinically, the usual duration is about 4–6 months,
with around 5 months being average depending on
skin thickness and metabolic rate.
In the first week, you see a filled-in look along with
mild swelling, and
it settles in over weeks 2–4,
when satisfaction is highest.
But it starts to gradually diminish after 3 months,
and by 6 months it returns to about 70–80% of the
pre-treatment level.
For people who exercise a lot or have a fast metabolism,
it may fade sooner, around 4 months.
Who Selrdiem suits well
vs. who may be better served by other treatments
Take a look and compare based on your situation.
Type | Recommended approach | Reason |
People with an important event 3–4 weeks away | Selrdiem | Immediate volume, quick settling |
People wanting long-term skin improvement | Juvelook · Rejuran | Stimulation-type treatment that boosts your own collagen production |
People who want to reduce maintenance cost | Stimulation-type treatments | Selrdiem needs replenishment every 4–6 months |
First-time collagen treatment | Combination treatment | Immediate effect + long-term contour building |
It is a good choice for those who need results in a short time,
but
over the course of a year, costs can add up.
So I recommend getting the quick effect while also
setting up a long-term stimulation-type treatment.
3 questions people really ask
before getting Selrdiem
Q1. Can you see results with just one session?
Yes, the volume itself is visible immediately after injection.
However, you should expect it to return to baseline after 4–6 months.
Think of it not as a 'one-and-done' treatment,
but as something that lasts about half a year.
Q2. How many times a year should I get it?
On average, 2–3 times a year at 4–5 month intervals.
At first, I recommend a touch-up at the 2-month mark to define the line,
then moving to 6-month intervals after that.
Q3. Does it become uneven as it fades?
Because it breaks down naturally,
it rarely fades in an irregular way.
However, for a few days after treatment,
tiny granules may be felt,
and if the depth is set incorrectly, they can become visible on the surface,
so expertise matters.
If you take away just one thing today —
Selrdiem is not a treatment that 'builds' but one that 'fills,'
and what is filled will eventually fade.
In the next post,
I’ll explain the interval when using Selrdiem together with
stimulation-type treatments.
This was Dr. Wi Young-jin.
Read more
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