Rejuran · DOT™ PN Polynucleotide

Skin to fill,
or skin to restore?

It's less about putting something in, and more about bringing your skin back to a state that can take it in.

DNA fraction from salmon · PN

If you break out often, there's something to sort out before injecting.

Rejuran 2mL 2-syringe package and prefilled syringe

For changes,
we allow 1 week.

It takes time for a damaged skin environment to settle. If you have an important event, we count backward from that date.

When change appears
Usually from about 1 week afterIt varies from person to person.
What goes in
DOT™ PN PolynucleotideA DNA fraction extracted from salmon in Korea.
Injection depth
The dermisA depth that ingredients applied on the surface don't reach.
Washing / Makeup
Possible the same dayAvoid scrubs and exfoliation for 2 weeks.

Rejuran's main ingredient is
just one: DOT™ PN.

It's a DNA fraction extracted from salmon in Korea. Rather than a material that fills, it's closer to a structure that makes room for the skin to recover on its own.

  • DNA fraction extracted from salmon in Korea
  • A safe, biocompatible substance
  • A colorless, transparent gel-type liquid that maintains a consistent viscosity
  • Keeps a certain form in the body and breaks down gradually
  • Naturally and temporarily improves facial wrinkles

Why the dermis

  • Stratum corneum
  • Epidermis
  • DermisDOT™ PNRejuran injection
  • Subcutaneous fat
Products you apply reach the outermost layer, the stratum corneum. Rejuran is placed below it, in the dermis. Because they reach different places, the speed at which change appears also differs. Its approved use in Korea is the temporary improvement of facial wrinkles in adults.

Before injecting,
there's something to sort out.

When frequent breakouts and sensitive conditions keep recurring, whatever is injected won't last long. This is because the skin has no capacity left for recovery.

Rejuran places DOT™ PN in the dermis. We see it as a sequence: the gel, which keeps a consistent viscosity, gradually breaks down inside the dermis and makes room for the skin to recover on its own.

Rejuran
comes in four types.

All four share the same main ingredient. The volume and added ingredients differ.

Rejuran product lineup packages and syringes
Rejuran product image · courtesy of PharmaResearch
  • DOT™ PNRejuran

    The basic formulation containing only the main ingredient. This is the product commonly called “Rejuran Healer.”

    2mL × 2 syringes
  • DOT™ PNRejuran i

    A smaller-volume formulation. Considered for narrow areas such as around the eyes.

    1mL × 1 syringe
  • DOT™ PNRejuran S

    A formulation used when addressing scars. We look at indented areas and acne scars together.

    1mL × 1 syringe
  • DOT™ PN + HA + lidocaineRejuran HB Plus

    Also contains hyaluronic acid and lidocaine. Considered when we look at hydration and discomfort during treatment together.

    1mL × 1 syringe

Specifications and ingredients are based on PharmaResearch's product information. Which product to use is decided at your consultation, based on the area and your skin condition.

From the day of treatment,
you can wash your face and wear makeup.

However, avoid scrubs, exfoliation, and peels for 2 weeks. For 3–7 days, also refrain from activities that raise your body heat.

What to know before treatment, and what to tell us
  • Embossing, redness, warmth, swelling, pain, or pimple-like bumps may occur and usually ease within a few days. The degree varies by person.
  • Needle bruising can last around 10 days.
  • Washing your face and applying makeup are fine on the day of treatment, but avoid scrubs, exfoliation, and peeling treatments for 2 weeks.
  • For 3 to 7 days after treatment, avoid heat-raising activities such as heavy drinking, saunas, jjimjilbang, hot baths, and intense exercise.
  • You may feel temporary dryness. Apply enough moisturizing cream and use sunscreen when going outside.
  • In very rare cases, allergic symptoms may occur. If swelling or itching lasts more than 3 days, please contact the clinic.
  • Please tell us before treatment about any medications you're taking or applying, and any previous injection treatments.
  • Risk cannot be guaranteed at zero.

Rejuran,
is it right for me?

Worth trying if this sounds like you

  • Your skin has become sensitive from frequent breakouts
  • Recurring inflammation is slowing your recovery
  • You want to address fine lines and skin texture together
  • Your under-eye shadows have been confirmed to come from thinned skin texture

In these cases, should we look at something else?

  • When under-eye shadows are caused by lost volume
    We first check options that reinforce dermal density (Re2o · CellREDM) or volume-based options.
  • When inner dryness and radiance are your main concerns
    We first consider HA-based options (Revive · Skinvive).
  • When indented scars are your biggest concern
    We consider an option that rebuilds dermal structure (Juvelook).
  • When pores and excess sebum are your main concerns
    We also look at Skin Botox.

Frequently Asked Questions

Is Rejuran a filling treatment?
No. It works to restore the skin environment. Using polynucleotides derived from salmon, it eases inflammatory response and strengthens the skin barrier, restoring the skin to a state where collagen can form. Its purpose is different from approaches that fill in volume.
Is Rejuran right for under the eyes?
If your under-eye shadow comes from thinned skin texture, it's a candidate. If it comes from lost volume, we look in a different direction. This varies significantly by individual, so it's decided during consultation.
How are Rejuran and Rejuran HB Plus different?
Rejuran Healer, as it's commonly called, is a general name for the basic formulation, Rejuran. The manufacturer lists four products, Rejuran, Rejuran i, Rejuran S, and Rejuran HB Plus, and all four have DOT™ PN as the main ingredient. Rejuran HB Plus also contains hyaluronic acid and lidocaine HCl. If you also have flushing, we consider HB Plus first.
Does it hurt a lot?
Everyone feels pain differently, so it's hard to say in advance how much it will hurt. We put particular care into nerve block anesthesia, often called a painless shot, and adding it makes the treatment noticeably easier. Rejuran is injected into the dermis, and Rejuran HB Plus also contains lidocaine HCl. If you're worried about pain, let us know at your consultation.
I can feel small bumps after treatment — is that normal?
Embossing can occur after injection-type treatments and usually eases within a few days. However, if swelling or itching lasts more than 3 days, please contact the clinic.
How many sessions do I need, and how are intervals decided?
Rejuran is usually done 3 times at 2-week intervals. However, this varies with skin condition and area, so we'll explain the plan after checking at your consultation and adjust it as we monitor your progress.
Which is better, Rejuran or Juvelook?
The two products have different main ingredients. Rejuran's main ingredient is DOT PN, and its approved use in Korea is the temporary improvement of facial wrinkles in adults. Juvelook Original is a collagen booster injected into the dermis. If you're looking to normalize the skin's cellular environment, we consider Rejuran; if you're looking to fill in fine lines and hydration, we consider Juvelook Original.
When should I get it before an important event?
Since bruising can last around 10 days, we count back from your event date to schedule the treatment. Redness and swelling generally subside within 1 to 2 weeks. Please let us know your schedule in advance.

You don't have to decide
on a product before you come.

Just jot down three things before your consultation. These three decide whether we sort out your skin environment first or look at another option first.

  1. How often breakouts occur and any changes over the last 3 months
  2. Whether your under-eyes look shadowed and whether the texture looks thin
  3. Any topical or oral medications you're currently using

For the current package, price, duration, and terms, please check the linked promotion page.

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