Rejuran · DOT™ PN Polynucleotide
Skin to fill,
or skin to restore?
It's less about putting something in, and more about bringing your skin back to a state that can take it in.
If you break out often, there's something to sort out before injecting.

For changes,
we allow 1 week.
It takes time for a damaged skin environment to settle. If you have an important event, we count backward from that date.
- When change appears
- Usually from about 1 week afterIt varies from person to person.
- What goes in
- DOT™ PN PolynucleotideA DNA fraction extracted from salmon in Korea.
- Injection depth
- The dermisA depth that ingredients applied on the surface don't reach.
- Washing / Makeup
- Possible the same dayAvoid scrubs and exfoliation for 2 weeks.
Rejuran's main ingredient is
just one: DOT™ PN.
It's a DNA fraction extracted from salmon in Korea. Rather than a material that fills, it's closer to a structure that makes room for the skin to recover on its own.
- DNA fraction extracted from salmon in Korea
- A safe, biocompatible substance
- A colorless, transparent gel-type liquid that maintains a consistent viscosity
- Keeps a certain form in the body and breaks down gradually
- Naturally and temporarily improves facial wrinkles
Why the dermis
- Stratum corneum
- Epidermis
- DermisDOT™ PNRejuran injection
- Subcutaneous fat
Before injecting,
there's something to sort out.
When frequent breakouts and sensitive conditions keep recurring, whatever is injected won't last long. This is because the skin has no capacity left for recovery.
Rejuran places DOT™ PN in the dermis. We see it as a sequence: the gel, which keeps a consistent viscosity, gradually breaks down inside the dermis and makes room for the skin to recover on its own.
Rejuran
comes in four types.
All four share the same main ingredient. The volume and added ingredients differ.

- DOT™ PNRejuran
The basic formulation containing only the main ingredient. This is the product commonly called “Rejuran Healer.”
- DOT™ PNRejuran i
A smaller-volume formulation. Considered for narrow areas such as around the eyes.
- DOT™ PNRejuran S
A formulation used when addressing scars. We look at indented areas and acne scars together.
- DOT™ PN + HA + lidocaineRejuran HB Plus
Also contains hyaluronic acid and lidocaine. Considered when we look at hydration and discomfort during treatment together.
Specifications and ingredients are based on PharmaResearch's product information. Which product to use is decided at your consultation, based on the area and your skin condition.
From the day of treatment,
you can wash your face and wear makeup.
However, avoid scrubs, exfoliation, and peels for 2 weeks. For 3–7 days, also refrain from activities that raise your body heat.
What to know before treatment, and what to tell us
- Embossing, redness, warmth, swelling, pain, or pimple-like bumps may occur and usually ease within a few days. The degree varies by person.
- Needle bruising can last around 10 days.
- Washing your face and applying makeup are fine on the day of treatment, but avoid scrubs, exfoliation, and peeling treatments for 2 weeks.
- For 3 to 7 days after treatment, avoid heat-raising activities such as heavy drinking, saunas, jjimjilbang, hot baths, and intense exercise.
- You may feel temporary dryness. Apply enough moisturizing cream and use sunscreen when going outside.
- In very rare cases, allergic symptoms may occur. If swelling or itching lasts more than 3 days, please contact the clinic.
- Please tell us before treatment about any medications you're taking or applying, and any previous injection treatments.
- Risk cannot be guaranteed at zero.
Rejuran,
is it right for me?
Worth trying if this sounds like you
- Your skin has become sensitive from frequent breakouts
- Recurring inflammation is slowing your recovery
- You want to address fine lines and skin texture together
- Your under-eye shadows have been confirmed to come from thinned skin texture
In these cases, should we look at something else?
- When under-eye shadows are caused by lost volume
We first check options that reinforce dermal density (Re2o · CellREDM) or volume-based options. - When inner dryness and radiance are your main concerns
We first consider HA-based options (Revive · Skinvive). - When indented scars are your biggest concern
We consider an option that rebuilds dermal structure (Juvelook). - When pores and excess sebum are your main concerns
We also look at Skin Botox.
Do you really
need Rejuran?
Getting everything isn't the default. A different treatment may suit your current concern better, so we've laid the options out below. Take a look and choose only what you need.
- Revive · Skinvive (HA)Handles cases involving dehydration, radiance, and skin density.
- Juvelook (PDLLA)Handles cases like pitted scars and rough texture, where the dermal structure needs to be rebuilt.
- Re2o · CellREDM (hADM)Handles cases requiring direct reinforcement of dermal density and volume.
- Skin BotoxHandles superficial skin concerns like enlarged pores and excess sebum.
Frequently Asked Questions
Is Rejuran a filling treatment?
Is Rejuran right for under the eyes?
How are Rejuran and Rejuran HB Plus different?
Does it hurt a lot?
I can feel small bumps after treatment — is that normal?
How many sessions do I need, and how are intervals decided?
Which is better, Rejuran or Juvelook?
When should I get it before an important event?
You don't have to decide
on a product before you come.
Just jot down three things before your consultation. These three decide whether we sort out your skin environment first or look at another option first.
- How often breakouts occur and any changes over the last 3 months
- Whether your under-eyes look shadowed and whether the texture looks thin
- Any topical or oral medications you're currently using
For the current package, price, duration, and terms, please check the linked promotion page.