Neck skin is thin—where polynucleotides go, how it differs from facial Rejuran, and care.
Horizontal lines on the neck are always visible regardless of your facial expressions, so many people find them bothersome every time they look in the mirror. While we often take great care of our faces, the neck is easily overlooked. However, once those neck wrinkles start catching your eye, it is very common to begin looking into treatments like Rejuran.
To give you a quick answer: yes, Rejuran-line treatments can certainly be considered for neck wrinkles. However, because the neck skin is thinner and undergoes much more movement than the face, we tend to take a slightly different approach. Understanding why neck wrinkles form and which layer of the skin Rejuran works on will make it much easier to choose the right method for you.
> This content is a summary of treatment information from Beauty stone in Hapjeong.
By reading this post, you will learn:
How neck wrinkles differ from facial wrinkles
Which layer of the skin Rejuran's key active ingredient works on
What makes neck treatments different from facial treatments
Essential pre- and post-treatment care tips
How do neck wrinkles differ from facial wrinkles?
The skin on the neck has a thinner dermis* and fewer sebaceous (oil) glands than the face. As a result, it dries out easily. Coupled with repetitive movements like looking down or turning your head, horizontal creases tend to settle in early. These folds can become even deeper with prolonged habits, such as using a high pillow or looking down at a smartphone.
Dermis*: The main layer of the skin located beneath the epidermis, which holds collagen and moisture to create elasticity.
While facial wrinkles are influenced by facial muscles and volume loss, neck wrinkles are largely caused by the inherent thinness of the skin, combined with a loss of moisture and elasticity. Therefore, rather than trying to fill volume, an approach focused on restoring the skin's surface and suppleness often works best for the neck.

Which layer of the skin does Rejuran's key ingredient target?
The core ingredient of Rejuran is polynucleotide (PN)*. These are DNA fragments extracted and purified from wild salmon. When injected into the dermal layer, they are known to help the skin retain moisture and build a healthy environment to heal itself.
Polynucleotide*: Small chain fragments that make up DNA, which help retain moisture and support tissue recovery in the dermis. It is commonly referred to as PN.
According to clinical evaluations reviewing the skin regeneration effects of polynucleotide injections, approximately 87.8% of participants showed moderate or higher improvement in the neck area, with no serious side effects reported. However, temporary reactions like swelling or redness can occur, so it is best to monitor your recovery closely.


What changes when treating the neck compared to the face?
The biggest differences lie in the depth of injection and dosage control. Because the neck skin is so thin, even the same active ingredients must be carefully and shallowly distributed. Also, since the neck moves constantly, minimizing irritation during the recovery process is key. Rather than trying to do everything in a single session, treatments are often spaced out over multiple sessions.
Category | Neck Treatment | Facial Treatment |
|---|---|---|
Skin Thickness | Thin | Thicker |
Injection Depth | Focused on shallower layers | Distributed by area |
Dosage | Delivered in small, split doses | Relatively generous |
Impact of Movement | High (due to neck rotation) | Low |
Recovery Care | Focus on posture and intense hydration | Focus on general hydration |
Since the neck is where horizontal creases form, your daily posture post-treatment will also affect your results. Here is a general timeline of how the treatment effects settle in.


Why choose Beauty stone in Hapjeong?
At Beauty stone in Hapjeong, we believe that areas with thin skin, like the neck, should not be over-injected all at once. Instead, we carefully assess your unique skin condition to plan out the precise depth and split dosages. Since everyone has different wrinkle depths and posture habits, we customize the treatment schedule and intervals just for you. With procedures personally performed by board-certified dermatologists, our cozy clinic located just steps from Hapjeong Station ensures a calm, personalized, and unhurried consultation experience.

Helpful tips for pre- and post-treatment care
While Rejuran-type treatments generally have minimal downtime, the neck is highly active, so proper care is essential to achieving stable, satisfying results.
Strenuous exercise & saunas on the day of treatment — Please avoid these for at least 24 hours, as heat and sweat can cause irritation.
Neck posture — Try to avoid looking down for long periods for a few days.
Moisturizing — The neck easily becomes dry, so be sure to apply a gentle moisturizer regularly.
Sun protection — Apply sunscreen to your neck as thoroughly as you do to your face.
Alcohol consumption — It is best to avoid alcohol for 1 to 2 days, as it can worsen swelling and redness.
Results usually emerge gradually over two weeks to two months, and the duration varies from person to person. For neck wrinkles, rather than expecting a one-time fix, it is ideal to schedule follow-up sessions based on how quickly your skin regenerates. Since this guide provides general information, please consult with a medical professional to safely determine if this treatment is right for you.

Frequently Asked Questions
Q. Can Rejuran really help with neck wrinkles?
A. Yes, polynucleotide-based treatments can be highly beneficial for neck wrinkles, with clinical studies showing clear improvements in the neck area. However, because neck skin is thin and moves constantly, a shallow, carefully distributed injection approach works better than the standard facial method. Designing a plan tailored to your specific wrinkle depth will yield the most natural results.
Q. Is a single session enough to see results?
A. While some individuals see noticeable changes after just one session, neck wrinkles typically require a series of spaced-out treatments. It is best to set the intervals based on how your skin recovers and regenerates. A personal consultation with our medical staff will help determine the safest and most effective number of sessions for you.
Q. Can I return to my daily routine immediately after the treatment?
A. Yes, the downtime is minimal, allowing for a quick return to your daily life. However, please avoid strenuous exercise and saunas on the day of the treatment, and try to avoid looking down for a couple of days. If you experience any temporary swelling or redness, rest well and monitor your skin's recovery.
Q. How long will the results last?
A. The effects typically build up over two weeks to two months and then gradually fade over time. The longevity depends greatly on your skin condition and lifestyle habits. Keeping the area well-moisturized and consistently applying sunscreen will help maintain your beautiful results longer.
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