Cellrediem vs. Rejuran HB, you need to understand the effects to choose.

Let me start with the conclusion.

Of the people who came for a Cellrediem consultation last month, seven out of ten

came in only knowing it was a good skin booster,

but they didn’t really know how it differs from Rejuran HB,

so I decided to write this article.

One-line conclusion. Cellrediem is a human allogeneic dermis-based skin booster with quick immediate effects.

How to choose. If dryness and fine lines are the issue, Cellrediem; if elasticity is the issue, Rejuran is the better fit.

What we’ll cover today. How to choose based on ingredients, number of sessions, and the possibility of nodules.

What you’ll see in this article

• The differences between Cellrediem ingredients and Rejuran HB

• The principle behind visible skin refinement after 2–3 sessions

• How to choose based on concerns such as dryness, elasticity, and worry about nodules

What is different about Cellrediem’s ingredients compared with Rejuran HB?

Cellrediem is based on allogeneic dermis.

Cellrediem uses human allogeneic dermis and is a skin booster mixed with HA.

Rejuran HB is best understood as a combination of PN and HA.

PN is short for polynucleotide, and it works more by stimulating skin regeneration signals.

Cellrediem should be viewed a little differently.

It tends to feel satisfying quickly for discomfort that is felt right on the surface, such as dryness and fine wrinkles.

On the other hand, Rejuran HB can be the better choice when approaching skin regeneration and elasticity with a longer-term view.

This is a bit confusing, because both are grouped under the name skin booster, so they can feel like the same treatment.

But in the clinic, we first separate whether the skin looks dull right now,

or whether it needs time for elasticity to improve.

Cellrediem’s effect comes down to immediate results and repetition over 2–3 sessions

The key point of this article

Cellrediem is a human allogeneic dermis skin booster,

and while it is similar to Rejuran HB’s PN + HA, it is still a different treatment.

It is good for immediate improvement.

When repeated 2–3 times, skin texture refinement and improved elasticity start to become visible.

This is a question I get about six times a week in the clinic.

The better question is not, “Is Cellrediem better than Rejuran HB?”

It is, “What problem does my skin need to solve first?”

When I look at Cellrediem’s effects, I divide them into two stages.

The first stage is the immediate change in moisture and fine surface wrinkles.

The second stage is the change after 2–3 sessions, when skin texture becomes more refined and elasticity gradually follows.

But there is one important thing here.

With skin boosters, results are not determined by “the ingredient is good” alone.

The results depend on which layer it is injected into, how densely it is placed, and how evenly it is distributed.

Honestly, this is something I hear in the clinic two or three times a week.

If you think of Cellrediem as a substitute for Rejuran HB,

and you receive Cellrediem,

then something like nodules appears.

When we checked, it seemed less like an inflammatory problem and more like localized accumulation in a shallow layer.

In cases like this, the issue is often not the ingredient itself, but the injection depth and spacing.

Even if the change looks similar on the skin surface, the direction of what is happening underneath is different.

With Cellrediem, the first thing people feel is a quick softening of dryness and fine wrinkles.

With Rejuran HB, you need to allow more time for the skin to recover based on PN’s regenerative signal.

So I do not only look at whether the skin has a glow one or two days later.

I also check after the second session,

the third session,

whether the texture felt by the fingertips during cleansing is different, and whether makeup sits less unevenly.

Key summary from Dr. Wi Young-jin

Cellrediem is not a lower-tier version of Rejuran HB.

For some people, Cellrediem is a better fit for immediate moisture and the feel of fine wrinkles,

while Rejuran HB may be more suitable when the focus is on regeneration and elasticity.

That said, neither is a treatment meant to end after just one session,

so it is generally safer to judge the outcome over a 3–4 session course.

If you are trying Cellrediem for the first time, what should you compare it with when choosing between it and Rejuran HB?

The starting point of the decision is the criterion.

If dryness and fine wrinkles are your main concern, the HA-containing Cellrediem option may provide higher immediate satisfaction.

If regeneration and improved elasticity matter more, many people first consider Rejuran HB.

There is one thing I must say clearly: Cellrediem is not universally good for everyone.

If it is injected too shallowly or clumps in one area, the embossing may last a long time or feel like a nodule.

Still, for people with severe dryness and thin fine wrinkles that are bothering them first, it remains a very good choice.

It becomes much clearer when you look at it in a table.

To be honest, if you choose based only on the cost difference, you may regret it.

More important than a difference of KRW 10,000–20,000 per session is the direction your skin needs right now.

For people whose main issue is dryness, I usually explain Cellrediem first,

and if elasticity loss is greater, I explain Rejuran HB alongside it.

Sometimes it is not about choosing one or the other,

but about separating the timing and the area for a more natural approach.

Cellrediem side effects and nodules: three questions that came up in the clinic

Q1. What is Cellrediem made of?

A. You should not think of Cellrediem as just the same kind of PN treatment as Rejuran HB.

Cellrediem is human allogeneic dermis extracted from humans.

Seven out of ten people who search about it ask, “So it’s almost the same as Rejuran, right?”

When I consult patients, I first explain whether it is based on human allogeneic dermis and whether HA is mixed in for an immediate effect.

When you look at it that way, it becomes easier to understand why it feels different.

By now, you may be wondering about this as well.

Q2. After how many sessions do you see Cellrediem’s effects?

A. Even one session is enough.

The two key effects are moisture and volume.

Before wrapping up, this part is really important.

Q3. Can Cellrediem cause side effects or nodules?

A. It is not very common, but if it accumulates too superficially, it can feel like a nodule.

We need to first distinguish embossing from a nodule.

If you take away just one thing today — think of Cellrediem first for quick hydration, and Rejuran HB first for deeper regeneration.


In the next article, I’ll explain “cases where a Cellrediem nodule remains and cases where embossing disappears.”


I’ll show with cases how the judgment changes on day 3 versus week 2, even in the same cheek area.


This was Dr. Wi Young-jin.

Also read

• Cellrediem vs. Rejuran HB, which one should I get?

• Cellrediem vs. Rejuran HB, which one is more suitable for me?

• Must-read 5 checks before Cellrediem treatment — the real conditions for regeneration and volume effects