CELLREDM vs. Rejuran HB,

What's the difference?

Both are called "skin regeneration injections,"

and everyone's talking about regeneration this, hydration that...

Honestly, it's hard to tell them apart, right?

Just because a treatment is popular

doesn't mean it suits everyone equally well.

Today, let's break down these two properly.

💡 Please check this before reading

Q. CELLREDM and Rejuran HB —

aren't they basically the same thing?

A. Their ingredient foundations are actually different.

They fall under the same "regeneration injection" category,

but their mechanisms and suitable goals differ.

Rejuran is PN-based.

CELLREDM is ADM-based (Human Acellular Dermal Matrix).

Q. Why are some people fine with just Rejuran,

while others are advised to get CELLREDM?

A. It depends on skin condition — particularly

whether there is volume loss.

I've broken this down in detail in the section below.

Q. So which one should I choose in my case?

A. It comes down to whether your goal is hydration and elasticity,

or volume restoration.

I've summarized it by type below.

Why do these two products keep getting

lumped together and confused?

One of the things I hear most often in the clinic is:

"Doctor, are Rejuran and CELLREDM

actually different?

I heard both are good for the skin."

It's a very common question.

And it's completely understandable to be confused.

Both are injectables,

and both show up when you search

skin regeneration.

But here's one key thing to know.

The two products start from completely

different ingredient foundations.

Rejuran HB is based on

PN (polydeoxyribonucleotide) extracted from salmon —

essentially DNA fragments.

It works by stimulating cellular regeneration signals,

and is particularly strong at improving skin texture

and boosting hydration and elasticity.

CELLREDM, on the other hand, is derived from

Human Acellular Dermal Matrix (인간동종진피),

meaning it utilizes the extracellular matrix (ECM) —

including collagen, elastin, and hyaluronic acid —

that remains after cells are removed from human dermal tissue.

Because its structural composition closely resembles

our own dermal layer,

it can go beyond simple regenerative stimulation

and also help directly restore volume.

It sounds technical, but simply put:

Rejuran HB sends stimulatory signals

to your skin cells,

while Celldiem is closer to

filling the empty spaces within the skin structure itself.

This difference matters because

if your goal is different,

so should your choice of product.

If your main goal is skin regeneration and hydration,

Rejuran HB may be sufficient.

If you're bothered by areas that have lost volume due to aging,

Celldiem is often the more suitable choice.

👨‍⚕️ Dr. Wi Youngjin's Key Takeaway

● Primarily focused on hydration and texture improvement

Rejuran HB may be the right fit.

● Concerned about volume loss or hollow areas

CELLREDMis the more appropriate direction.

● Both apply to you

Combination treatment is also an option.

I'll explain this further below.

Rejuran HB:

Who is it right for?

The Rejuran series

is already well known.

The HB version specifically is a formulation

with added Hyaluronic Acid.

On top of PN cellular regeneration effects,

it's designed to boost hydration at the same time.

These are the cases where I typically recommend

Rejuran HB:

1. Rough skin texture with insufficient moisture

2. Fine lines and skin thinning as the main concerns

3. As a supplementary treatment to support skin recovery after regenerative laser procedures

4. Wanting to manage overall skin condition

In my experience, Rejuran HB is typically administered

at around 1–2cc for the full face per session,

and skin texture changes are usually noticeable

after 3–4 sessions at 4-week intervals.

That said, it's not a perfect solution.

One downside of Rejuran HB is that

its direct volume-filling power is limited.

It clearly works for regeneration and hydration, but

if hollowness or sagging is your main concern,

Rejuran HB alone

often leaves something to be desired.

Still, for those focused on texture improvement and moisture care,

it remains a very good choice.

👨‍⚕️ Dr. Wi Youngjin's Key Takeaway

● Rejuran HB

Strong in hydration, regeneration, and texture improvement

Limited volume-correction effect

Suitable for overall skin condition management

● Treatment cycle

3–4 sessions at 4-week intervals

is the standard approach

for seeing meaningful skin texture changes.

Celldiem: Why is it a different choice

for skin with volume loss?

"Doctor, my skin feels dry and dull,

and my cheeks look hollow."

I hear this kind of concern

often in the clinic.

In these cases,

it's not just about lacking moisture.

The structures within the dermis —

collagen, elastin, and the extracellular matrix itself — have decreased,

causing the skin to thin and lose volume.

Celldiem takes a different approach to this problem.

Because its human allogeneic dermis-derived components

closely resemble the structure of the dermal layer,

after injection it provides physical volume support at the site

while simultaneously inducing regeneration

of surrounding cells.

To be honest,

when I first encountered this product,

I was skeptical too.

I needed time to verify whether

human-derived components were safe

and whether the volumizing effect was genuinely different.

After accumulating real cases myself,

for patients whose main concern was cheek hollowness or

reduced volume in the forehead and temples,

Celldiem consistently showed

a more noticeable perceived improvement than Rejuran HB.

These are the cases where I typically recommend

Celldiem:

1. Volume loss in specific areas such as the cheeks, forehead, or temples

2. Those who don't want fillers but still need volume improvement

3. Those who want both dermal regeneration and volume maintenance

4. Those whose main concern is a hollow look from skin thinning

In my experience, Celldiem is usually administered

at around 1–2cc per area,

typically over 2–3 sessions

at 4–6 week intervals.

Some patients notice visible volume changes

as early as the first or second session.

There's one thing I should definitely mention:

the downside is cost ^^..

Compared to Rejuran HB, Celldiem

tends to have a higher unit price.

That's because the manufacturing cost

of human allogeneic dermis material is inherently higher.

That said, for those with a clear volume-related goal,

the results

often justify the difference in cost.

For reference, skin regeneration procedures that work synergistically

with Celldiem

are also covered in our skin booster guide by type,

so reading that together may be helpful.

👨‍⚕️ Dr. Wi Youngjin's Key Takeaway

● Celldiem

Volume support + dermal regeneration — both at once

Relatively higher cost

Best suited for those whose main concern is volume loss

● Rejuran HB

Focused on hydration, regeneration, and texture improvement

Limited volume-correction effect

Best suited for overall skin condition management

So what about doing both

together?

This is a common misconception, but

Celldiem and Rejuran HB can absolutely be combined.

They're not competitors —

they work at different layers of the skin.

It varies by case, but

here's how I usually approach it.

For patients dealing with both volume loss

and hydration or texture issues,

I first establish volume support with Celldiem,

then use Rejuran HB to address skin texture

and moisture balance.

The tricky part is that

when doing both at the same time,

the dosage and area allocation shift

depending on which issue takes priority.

So if you're considering combination treatment, it helps to clearly communicate

"what's bothering you the most right now"

during your consultation.

When I combine these two products,

I build the volume structure first with Celldiem,

then layer Rejuran HB on top

for additional skin-regeneration benefits.

👨‍⚕️ Dr. Wi Youngjin's Key Takeaway

● Sequence for combination treatment

Celldiem (establish volume structure)

→ Rejuran HB (add regeneration and hydration)

● Key point

If you need both,

start by identifying which issue is more urgent.

Key Summary

Celldiem vs. Rejuran HB

If your goal is hydration and regeneration, go with Rejuran HB.

If your goal is volume restoration, Celldiem is the more suitable choice.

Frequently Asked Questions

Q1. Celldiem uses human-derived components — is it safe?

A. Some people feel uneasy

when they hear it's based on human allogeneic dermis.

The human allogeneic dermis used in Celldiem

is in a fully decellularized

Acellular Matrix state,

which means immune reactions are low.

Of course, individual differences exist, so allergy history

and related factors must be confirmed during the pre-treatment consultation.

Rather than declaring it unconditionally safe,

I recommend making the decision

based on your own condition after a proper consultation.

Q2. Rejuran HB and Celldiem —

how long do the effects last?

A. In my experience, Rejuran HB's hydration

and texture improvement effects

often last around 3–6 months after treatment,

while Celldiem's volume effect

tends to last around 6 months to 1 year in many cases.

That said, this varies quite a bit depending on individual skin condition, lifestyle,

and treatment area.

I generally avoid definitive statements

like "guaranteed for X months."

Q3. How is it different from fillers?

A. I get this question all the time.

Celldiem does have a volume-support effect,

but unlike fillers, it does not create

an immediate, dramatic change in volume.

Fillers directly inject hyaluronic acid

to produce instant volume,

whereas Celldiem reinforces the dermal structure

and works more gradually toward restoring volume.

If you want immediate and pronounced volume results,

fillers are the more suitable option.

If you'd prefer natural improvement of the skin itself

while also restoring volume over time,

Celldiem is the better fit.

I recommend having a thorough consultation

before making your decision.

If you have any questions,

feel free to reach out to us on KakaoTalk.

You're welcome to ask before visiting the clinic.

This has been Dr. Wi Youngjin.

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