If you've started noticing fine lines at the corners of your eyes — the kind that seem to multiply when you smile — you're not alone. The skin around your eyes is the thinnest on your face, which makes it the first place to show signs of aging, dryness, and repeated muscle movement. In this article, we'll cover how Rejuran HB works on eye-area wrinkles, when it's enough on its own, and when combining it with Botox or another booster makes more sense.

What Is Rejuran HB?

Rejuran HB is a skin booster that combines three active components: PN (polynucleotide) derived from salmon DNA, hyaluronic acid (HA), and lidocaine. Together, they aim to repair skin at the cellular level, improve hydration, and reduce injection discomfort. The PN component works by activating fibroblasts — the cells responsible for producing collagen and elastin. Research published on PMC (PMC11902836) indicates that polynucleotides can stimulate skin repair and collagen synthesis, which is the core mechanism behind Rejuran's effect on fine lines.

What sets Rejuran HB apart from the original Rejuran Healer is the added HA component, which gives an immediate plumping and hydrating effect on top of the slower, longer-term tissue repair from PN. The lidocaine helps make the injection more comfortable — particularly useful in the sensitive eye area.

What Causes Eye Wrinkles — and Why It Matters for Treatment

Not all eye wrinkles are the same, and the cause makes a real difference in how you treat them. Here's a quick breakdown:

Rejuran HB addresses the first category well — dry, thin skin with static fine lines. If your main concern is crow's feet that deepen every time you laugh, or structural hollowing under the eye, you'll likely need a different or additional approach.

When Rejuran HB Alone Can Be Enough

The short answer? When the issue is primarily skin quality, not muscle movement or volume.

Rejuran HB tends to be a strong standalone option if you're dealing with:

• Fine, crepey lines around the eye that are visible even without expression

• Dry, rough skin texture around the eye that doesn't respond to topical moisturizers

• Early-stage thinning of the under-eye skin in your 20s or early 30s (think: prejuvenation)

• Dull, fatigued-looking skin around the eyes with no major sagging or deep wrinkles

Individual results vary depending on your skin condition, lifestyle, and age of the wrinkles. In general, a series of two to three sessions spaced three to four weeks apart is typical for an initial round, followed by maintenance every three to six months. Your provider will assess what's right for you based on your skin.

When Adding Botox Makes Sense

If crow's feet are your main concern — lines that appear only when you smile or squint and disappear at rest — Rejuran HB alone may not address the root cause. Those are dynamic wrinkles, driven by the orbicularis oculi muscle contracting every time you make an expression.

In this case, combining Rejuran HB with periorbital Botox can be a complementary approach:

• Botox's role: Temporarily relaxes the muscle, reducing the depth and frequency of expression wrinkles

• Rejuran HB's role: Repairs the thin, damaged skin and improves its overall quality — so when the Botox takes effect, the underlying skin looks healthier

That said, Botox around the eye requires precise dosing and placement. Even a small miscalculation can affect your ability to lift your brow or close your eye fully. This is a conversation to have in detail with a qualified provider — not a decision to make based on a general article. For pricing details, see /en/price and /en/promotion.

Side Effects & Safety: What to Expect

Because the skin around the eye is so thin, it's more prone to bruising after injection than other areas of the face. Redness, mild swelling, and small bruises are common and usually settle within three to seven days. If swelling worsens after 48 hours, spreads beyond the injection site, or you notice any changes in your vision, seek medical care right away.

Rejuran HB is generally not recommended if you:

• Are pregnant or breastfeeding

• Have an active infection or inflammation near the treatment area

• Are allergic to salmon or any component of the formula

• Have an autoimmune condition that is not well controlled

Like any injectable procedure, it comes with trade-offs. Understanding them upfront helps you plan your timing — avoid major events in the week after treatment.

How Does It Fit Into a Broader Skincare Approach?

Rejuran HB works best when it's part of a consistent skin-maintenance approach rather than a one-time fix. Pairing it with daily SPF use and a hydrating skincare routine can help the results last longer. If you're also doing energy-based treatments like RF or HIFU, your provider can help you sequence them so they don't interfere.

It's also worth noting that the eye area is a high-movement zone. Results here tend to require more frequent maintenance than other facial areas — something to factor into your planning. Individual results vary, and your provider is the best source of realistic expectations for your specific skin.

The Bottom Line

Rejuran HB can be a solid standalone option for fine, static eye wrinkles caused by skin thinning and dehydration. But if crow's feet from muscle movement are your primary complaint, or you're dealing with structural hollowing or sagging, you'll get more out of a combined approach. Below is a quick recap:

• Static fine lines from dry, thin skin: Rejuran HB on its own is worth trying first

• Dynamic crow's feet from muscle movement: Consider adding Botox

• Volume loss or sagging: May need filler or a lifting treatment — discuss with your provider

Ultimately, the right path depends on your skin, your goals, and what you're starting with. A proper in-person assessment is the only way to know for certain. BeautyStone is a dermatology clinic in Seoul's Hapjeong area. If you're considering Rejuran HB for your eye area, see what's currently available at /en/promotion.