For painless Rejuran, HB Plus is the usual pick, but results differ from Healer, so pick by goal.
Published -
Updated -
Author
Wi Young-jin · Chief director
Seoul National University College of Medicine · Seoul National University Hospital Specialist
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If you're looking into Rejuran but find yourself thinking "I'm too scared of the pain," the HB Plus option is frequently mentioned. To put it simply, HB Plus is the pain-relief version, while the original Healer belongs to the pure PN* line, making their benefits slightly different. Your choice will depend on your skin condition and your pain tolerance.
The Rejuran Lineup — What's the difference between Healer, HB, and HB Plus?
There are several options under the Rejuran brand. While they are all based on Polynucleotide (PN), their ingredient concentrations and functions differ:
Line | Key Ingredients | Primary Target | Pain Level |
|---|---|---|---|
Rejuran Healer | PN 2% | Dermal regeneration & texture improvement | Relatively the highest |
Rejuran HB | PN + HA Complex | Hydration & texture improvement | Moderate |
Rejuran HB Plus | PN + HA + Anesthetic | Pain relief + Hydration | The lowest |
Think of the Healer as the original, with HB and HB Plus being extensions of the line designed to make the treatment process much more comfortable.
*PN (Polynucleotide): DNA fragments extracted from salmon testes. It is an ingredient widely known for stimulating skin cell proliferation and regeneration.
How HB Plus Reduces Pain
There are two main reasons why HB Plus is much more comfortable than regular Rejuran during the procedure:
Contains a local anesthetic — Blocks pain signals during the procedure.
Adjusted viscosity with HA — Reduces the pressure and discomfort during injection.
However, since it contains an anesthetic, it is very important to share your allergy history beforehand. For those with a lidocaine* allergy, the regular Healer is recommended instead of HB Plus.
*Lidocaine: A local anesthetic used to reduce pain during treatments. As rare allergic reactions can occur, sharing this information in advance is essential.
The Safety Guide for Non-Surgical Cosmetic Procedures also emphasizes the importance of pre-checking for allergies before treatments involving anesthetic components.
Benefits — Same lineup, but different focus
Here is a quick summary of how the benefits of the three lines compare:
Item | Healer | HB | HB Plus |
|---|---|---|---|
Dermal Regeneration Intensity | High | Moderate | Moderate |
Immediate Hydration | Mild | High | High |
Texture & Elasticity Improvement | High | Moderate | Moderate |
Results per Session | Significant | Moderate | Moderate |
Recommended Sessions | 3–4 sessions | 2–3 sessions | 2–3 sessions |
Generally speaking, if you want intensive dermal regeneration, Healer is the way to go. On the other hand, if you want to see quick hydration, the HB line is ideal. HB Plus offers similar benefits to HB, but with a focus on minimizing pain.
Sessions are typically recommended every 2 to 4 weeks. Please consult with our medical team to tailor a schedule to your skin's recovery speed and your travel plans.
Which line is right for you?
Here is a simple guide to aid your selection, based on individual preferences:
For those with a low pain threshold or first-timers → HB Plus is recommended
For those wanting intensive texture & elasticity improvement → Healer is recommended
For those looking for rapid hydration & texture improvement → HB or HB Plus
For those with a history of lidocaine allergy → Healer (anesthetic-free)
If you are pregnant or breastfeeding → Please postpone the procedure (applies to all lines)
If you have active inflammation or acne in the treatment area → We recommend treating after the skin has fully recovered
Cases that require immediate consultation with our medical team:
A history of side effects from PN-based treatments
A diagnosis of an autoimmune disease
Currently taking anticoagulants or high doses of Vitamin E
The best choice comes down to your personal skin assessment, pain tolerance, and schedule. Sharing details about your lifestyle during your consultation helps us find the absolute perfect match for you.
Frequently Asked Questions
Q. Is HB Plus less effective than Healer?
A. Rather than "less effective," it is more accurate to say "their focus is different." HB Plus shines in pain reduction and rapid hydration, while Healer focuses heavily on deep dermal regeneration and skin quality. If your main goal is instant moisture, HB Plus is highly recommended; for deep skin renewal, Healer is the traditional favorite.
Q. Which line is best if it's my first time?
A. Many of our guests who are concerned about pain choose to start with HB Plus. Its ease of treatment makes it a very comfortable first experience, and some guests choose to transition to Healer for subsequent sessions. We invite you to speak with our medical team to balance your priorities (pain relief vs. treatment intensity).
Q. How far apart should my sessions be?
A. We generally recommend an interval of 2 to 4 weeks. Intervals may need to be adjusted depending on your skin's recovery phase, skin condition, and other concurrent treatment schedules (such as Botox or fillers). Please be sure to share any other recent treatment history during your consultation.
This content is for general information purposes. To see which treatment is best suited for you, please consult directly with our medical providers.
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