What You Must Know Before Getting Rejuran in Seoul

Hello.
I'm Dr. Wi Young-jin, a specialist at Beautystone Clinic.

One question I get asked all the time is,

"What does Rejuran actually do?"

There's no shortage of content out there,

but finding truly useful information? That's a different story.

Check out these posts too!

✦ Related Reading

• ▶Skincare Routine for Brides-to-Be: A Day-by-Day Guide Before the WeddingBS

• ▶Forehead Wrinkle Botox: Effects & How Long It LastsBD

• ▶Nose Filler: Side Effects, Results & LongevityBS

• ▶Does Mounjaro Really Cause Skin Sagging?BD

• ▶ulthera+Thermage Swelling: When Does It Go Down?BS

For those searching for Rejuran
in Seoul — especially around Hongdae and the surrounding area —

here's what I've learned from 5 years of clinical experience.

Rejuran, PN, HA: Ingredients & Treatment Overview

Medical papers can be dense, right?

Let me break down two key studies for you.

The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review - Lampridou - 2025 - Journal of Cosmetic Dermatology - Wiley Online Library

This study isn't the highest level of evidence,

reducing wrinkles, improving skin texture, and enhancing elasticity, with statistically significant results in several studies

In short: fewer wrinkles, smoother texture, and firmer skin.

Polydeoxyribonucleotides as Emerging Therapeutics for Skin Diseases: Clinical Applications, Pharmacological Effects, Molecular Mechanisms, and Potential Modes of Action

Rejuran Healer, PN 20mg/ml

1. Increased skin thickness,

2. reduced wrinkles,

3. improved skin texture

   
   
   

   In a randomized split-face trial of 27 participants, the PN-treated side showed significantly higher GAIS scores at week 16 compared to HA filler, and greater reduction in skin roughness by week 28.

1. Know Exactly What Rejuran Is Before You Get It

Rejuran
is a polynucleotide (PN) extracted from salmon,

It's injected directly into the skin.

Simply put, it contains the building blocks of cells —

fragments of DNA.

So what does it actually do?

1. Anti-inflammation & regeneration.

PN stimulates collagen synthesis and promotes new blood vessel formation.

1. Improves aging signs and fine lines.

Collagen synthesis fills in fine lines and minimizes pores — anti-aging effect.

1. Improves depressed acne scars (cell regeneration).

Collagen fills in sunken scar areas, gradually lifting them up.

1. Restores skin barrier + reduces sensitivity.

   Damaged skin barrier regenerates, bringing sensitive skin back to its normal state.

✔ This is not a volume-filling treatment like filler,
✔ nor does it affect muscles like Botox.

It works by helping skin cells produce collagen on their own —
which is why results look natural.

Many patients in Seoul ask about Rejuran:

"Will I see a big difference after just one session?"

Honestly speaking,

rather than dramatic changes,
think of it this way: 2. Who is it most effective for?They absorb naturally on their own.

In my clinical experience,

there are certain skin types that respond especially well to Rejuran 👇
✔ Rough skin texture and enlarged pores from severe acne in younger years

✔ Fine lines from thinning skin
✔ Overall loss of elasticity
Satisfaction tends to be high in these cases.

On the other hand,

❗ Deep nasolabial folds

❗ Significant volume loss
For these concerns,

Rejuran alone isn't the right choice.

In those cases,

combining filler or other treatments is recommended.
Based on patients visiting our clinic in Seoul,

"Is something wrong with my skin at this age?"

tend to report the highest satisfaction.
Late 30s to early 50s

No skin concerns? Rejuran may not be necessary.

Rejuran HB is a great option though → for a glass-skin glow effect.

📊 Rejuran Suitability Summary

Concern

Rejuran is performed

with numbing cream applied beforehand.
👉 Treatment time is approximately 30 minutes.

After the procedure,

🔺 small bump-like papules may appear

🔺 for about 1–3 days.
This is not a side effect —

it's simply PN settling into the skin,
a normal response. 📌 Post-treatment precautionsThey absorb naturally on their own.

✔ Avoid cleansing and makeup on the day of treatment

✔ No intense exercise

✔ Limit alcohol consumption
📌 Duration of results
👉 Average 6–12 months

👉 After 3–4 sessions spaced 2–4 weeks apart,

maintenance sessions are recommended.

Some patients coming from the Hongdae area say,
"I had one session and didn't notice any difference."

This is something we hear from time to time.

"1회 했는데 효과 없어요"

이렇게 말씀하시는 경우도 있는데요

Rejuran is
A treatment where results compound over time😊

Frequently Asked Questions (FAQ)

Q1. Why does Rejuran pricing vary by clinic?

A. Rejuran is a non-covered procedure, so pricing differs between clinics.

✔ Product type (Healer / Eye, etc.)
✔ Treatment area
✔ Doctor's experience

These factors all affect the price.

Also,
Whether the procedure is performed directly by the doctoris another key difference.

At Beautystone Clinic,
we provide transparent pricing during consultation.

Q2. Does Rejuran hurt?

A. We apply numbing cream beforehand,

so most patients find it very manageable.

There's a mild stinging sensation, but

✔ the procedure is quick
✔ and intensity can be adjusted,

so discomfort is minimal.

If you have sensitive skin,
just let us know 🙂

Q3. Can I combine Rejuran with fillers or Botox?

A. Yes, combination treatments are possible.

They can actually enhance each other's results.

However, too many procedures in one visit can be taxing,

so it's best to tailor the combination
to your skin condition.

If you're considering Rejuran in Seoul,

what matters most is
a plan designed for your skin.

At Beautystone Clinic in Hongdae,

✔ I personally handle every consultation
✔ and perform every procedure myself

We're also open on Sundays,

so if your schedule is tight,
feel free to visit anytime 🙌

Related post: 5 Safety Checklists to Prevent Accidents During Ulthera Sedation | Ulthera Results: How Many Shots Does It Take to See a Difference?